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季少平
2015-01-14 18:19  
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季少平,医学博士,教授,博士生导师。1999-2003工作于第四军医大学肿瘤生物学国家重点实验室、生化与分子生物学教研室讲师、副教授。获军队科技进步一等奖(第三)一次。2003-2011先后作为博士后和research associate工作于加拿大Saskatchewan大学医学院,获得Saskatchewan省健康研究基金全额资助。2011受聘河南大学医学院教授,黄河学者。主持过三项国家自然科学基金面上项目,作为主要参与人参与国家973和863计划/项目。2012年获河南省科技创新杰出人才基金资助。主要研究领域/方向为:分子生物学/PTEN调控的细胞信号转导(肿瘤生物学);非编码RNA参与的基因表达与调控; Sirt2 调控少突胶质细胞分化。主要研究发表在Nature Medicine(第一作者,影响因子32.62), Journal of Clinical investigation, Journal of Molecular Cell Biology,Journal of Cellular and Molecular Medicine, American Journal of Cancer Research和Viruses等杂志发表文章。总影响因子165.22。共被引用1542次(Google scholar,截止2018.07.08)。参编专著Methods MolBiol(Springer)关于Sirt2的章节。担任多家国际期刊Theranostics, Oncotarget, Cell Physiol Biochem, molecular basis of disease, Journal of Cellular Physiology, European Journal of Cell Biology等的评阅人,TheraPTEN公司的科学顾问。

教育经历

1986毕业于第四军医大学医学系

1993毕业于军事医学科学院基础所(三所),获硕士学位。

1999毕业于第四军医大学生物化学与分子生物学系,获博士学位

工作经历

1999-2003第四军医大学讲师,肿瘤生物学国家重点实验室

2003-2008第四军医大学副教授,肿瘤生物学国家重点实验室

(其间, 2003-2007加拿大Saskatchewan大学,博士后,获得省健康研究基金全额资助)

2008-2011加拿大Saskatchewan大学,research associate,实验室负责人

2012河南大学特聘教授,黄河学者,教授(兼职Saskatchewan大学,research associate,)

2012河南省生理学会常务理事、神经生物学专业委员会副主委

2012河南省生物化学与分子生物学学会常务理事

1999中国生物化学与分子生物学会会员

获奖情况

1996军队科技进步二等奖,“高热引起热损伤的肾上腺素受体机理及抗热损伤研究”,第五完成人

1999军队科技进步一等奖“蛋白酪氨酸激酶Btk在细胞内外与蛋白激酶PKC相互作用的研究”,第三完成人

1999第四军医大学教学先进个人,2001第四军医大学教学先进个人

2001陕西省优秀博士论文获得者

科研基金专利情况

1.河南省自然科学基金,长非编码RNA调控PTEN-long表达分子机制研究,2017.01-2019.12,10万元,在研,主持。

2.河南省高等学校重点科研项目,17A310004,PTEN假基因PTENP1介导的PTEN-long表达分子机制研究,2017.01-2018.12,5万元,在研,主持。

3.国家自然科学基金项目,批准号:31371386。PTEN调节ERK5信号影响神经细胞分化的机制研究。2014.1-2017.12,资助7万元,主持人,国家自然科学基金委立项

4.西部提升计划,河南大学科技创新团队资助计划:2014-2015,资助80万。

5.河南省科技创新杰出人才基金,批准号:124200510010,PTEN介导的ERK5信号对PC12细胞分化的调节作用. 2012.1-2014.12,资助50万。主持人,河南省科技厅。

6.河南大学黄河学者启动基金2012-2016,50+15万

7.国家自然科学基金项目,批准号:30871239。单泛素化PTEN的核转位与少突胶质细胞分化抑制。2009.1-2011.12,资助31万元,主持人,国家自然科学基金委立项。

8.国家自然科学基金项目,批准号:30570676。NDRG2在细胞低氧应激反应中的作用及机制研究。2006.1-2008.12,资助25万元,主持人,国家自然科学基金委立项,已结题

9.国家重大基础理论研究发展(973)计划,“炎症的细胞信号转导网络及其调控机制”。项目编号2002CB513000, 2003-2007年。分题参与者,已结题。

10.国家863课题:“氨抗美”注射液的研制(2001AA215321)。2001-2005年,参与者,已结题

11.GFP-CD19融合蛋白及其在细胞标记方面的应用(CAR-T质控)。申请号:201610354642.0。第一完成人

发表文章

1.Fang N, Gu T, Wang Y, Wang S, Wang F, An Y, Wei W, Zhang W, Guo X, Nazarali AJ,Ji S*.Expression of PTEN-long mediated by CRISPR/Cas9 can repress U87 cell proliferation.J Cell Mol Med. 2017 Jun 19. doi: 10.1111/jcmm.13236. [Epub ahead of print]

2.Wei W, Ji X, Guo X,Ji S*.Regulatory Role of N6 -Methyladenosine(m6 A) Methylationin RNA Processing and Human Diseases.J Cell Biochem. 2017 Mar 3. doi: 10.1002/jcb.25967. [Epub ahead of print])

3.Wei W, Wang H,Ji S*.Paradoxes of the EphB1 receptor in malignant brain tumors. Cancer Cell Int. 2017 Feb 8;17:21. doi: 10.1186/s12935-017-0384-z.

4.Thangaraj MP, Furber KL, Gan JK,Ji S, Sobchishin L, Doucette JR, Nazarali AJ. RNA binding protein Quaking stabilizes Sirt2 mRNA during oligodendroglial differentiation. J Biol Chem. 2017 Feb 10. pii: jbc.M117.775544. doi: 10.1074/jbc.M117.775544.

5.Di Y, Ji S, Wolf P, Krol ES, Alcorn J. Enterolactone glucuronide and β-glucuronidase in antibody directed enzyme prodrug therapy for targeted prostate cancer cell treatment. AAPS PharmSciTech. 2017 Jan 23. doi: 10.1208/s12249-017-0721-5.

6.Yang An, Haojie Wang, Jingyao Jie, Yitai Tang, Weijuan Zhang,Shaoping Ji*, Xiangqian Guo*. Identification of distinctmolecular subtypes of uterine carcinosarcoma Oncotarget,Oncotarget.2017 Feb 2. doi: 10.18632/oncotarget.15032. [Epub ahead of print]

7.Yang An,Kendra L.Furber,Shaopig Ji*. Pseudogenes Regulate Parental Gene Expression via ceRNA Network. Journal of Cellular and Molecular Medicine. 2016 Aug 25. doi: 10.1111/jcmm.12952. [Epub ahead of print]

8.Shaoping Ji, Doucette JR, Nazarali AJ.Protocols for Cloning, Expression, and Functional Analysis of Sirtuin2(SIRT2).Methods Mol Biol. 2016;1436:189-99. doi: 10.1007/978-1-4939-3667-0_13.

9.Fengling Wang, Adil J. Nazarali,Shaoping Ji*. Circular RNAs as potential biomarkers for cancer diagnosis and therapy. American Journal of Cancer Research. 2016, 6(6):1167-1176

10.Wenqiang Wei, Hongju Wang, Xiaoya Li, Na Fang, Shili Yang, Hongyan Liu, Xiaonan Kang, Xiulian Sun, andShaoping Ji*, Cloning and Characterization of Sf9 Cell Lamin and the Lamin Conformational Changes during Autographa californica multiple nucleopolyhedrovirus Infection. Viruses 2016, 8, 126; doi: 10.3390/v8050126

11.Fang N, Zhong N, Yang Y, Guo Y,Ji S*.Data of expression and purification of recombinant Taq DNA polymerase.Data Brief. 2016 Aug 20; 9:81-4. doi: 10.1016/j.dib.2016.08.032. eCollection 2016 Dec.

12.Yamei Hu, Yang An, Na Fang, Yanzhang Li, Haiying Jin, Adil Nazarali,Shaoping Ji*.The Optimization of Soluble PTEN Expression in Escherichia coli.The Open Biochemistry Journal, 2015, 9: 42-48

13.Wang J, Sun Z, Shen J, Wu D, Liu F, Yang R,Ji S, Ji A, Li Y.Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB.Oxid Med Cell Longev. 2015; 970156.

14.Wu D, Zheng N, Qi K, Cheng H, Sun Z, Gao B, Zhang Y, Pang W, Huangfu C,Ji S, Xue M, Ji A, Li Y.xogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential.Med Gas Res. 2015;5(1):1.

15.Wang J, Wang S, Li M, Wu D, Liu F, Yang R,Ji S, Ji A, Li Y.The Neuropilin-1 Inhibitor, ATWLPPR Peptide, Prevents Experimental Diabetes-Induced Retinal Injury by Preserving Vascular Integrity and Decreasing Oxidative Stress.PLoS One. 2015 Nov 10;10(11): e0142571.

16.Yinguo Bai, Na Fang, Tingxun Gu, Yuhua Kang, Jiang Wu, Desheng Yang, Hui Zhang, Zhimin Suo andShaoping Ji*.HOXA11 gene is hypermethylation and aberrant expression in gastric cancer.Cancer Cell International 2014 Aug 19;14:79

17.Wang T, Jia L, Yang G,Ji S, Yao L, Zhang B.Identification of Juxtanodin promoter and its transcriptional regulation during the ATRA-induced differentiation of C6 cells.Mol Cell Biochem. 2011 Apr;350(1-2):177-83.

18.Shaoping Ji, Ronald Doucette, and Adil J. Nazarali. Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation.J Mol Cell Biol.2011;3(6):351-9

19.Jia L,Ji S(co-first author), Maillet JC, Zhang X.PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3-kinase and MAP kinase signaling.J Cell Biochem.2010; 111(6):1390-400.

20.Dang N, Hu J, Liu X, Li X,Ji S, Zhang W, Su J, Lu F, Yang A, Han H, Han W, Jin B, Yao L.CD167 acts as a novel costimulatory receptor in T-cell activation.J Immunother. 2009 Oct;32(8):773-84.

21.Wang L, Liu N, Yao L, Li F, Zhang J, Deng Y, Liu J,Ji S, Yang A, Han H, Zhang Y, Zhang J, Han W, Liu X (2008). NDRG2 is a new HIF-1 target gene necessary for hypoxia-induced apoptosis in A549 cells.Cell. Physiol. Biochem. 21:239-250.

22.Liu N,Wang LF,Li X, Yang Q,Liu XP,Zhang J, Zhang J, Wu YS,Ji SP, Zhang YQ, Yang AG, Han H and Yao LB. N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis.Nucleic Acids Research, 2008, 1–15

23. Ji, S, Zhang, Y, Van Cleemput, J, Jiang W, Wan Q, Backstrom JR, Zhang X (2006). Disruption of protein-protein coupling between PTEN and serotonin 5-HT2C receptor suppresses marijuana-induced rewarding effects.Nature Medicine. 12:324-329.

24. Zhang J, Li F, Liu X, Shen L, Liu J, Su J, Zhang W, Deng Y, Wang L, Liu N, Han W, Zhang J,Ji S, Yang A, Han H, Yao L (2006). The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter.J Biol Chem. 281:39159-39168.

25. Jiang W, Zhang Y, Xiao L, Van Cleemput J,Ji SP, Bai G, Zhang X (2005). Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.J Clin. Invest. 115(11): 3104-3116.

26. Jiang W, Van Cleemput J, Sheerin AH,Ji S, Zhang Y, Saucier DM, Corcoran ME, Zhang, X (2005) Involvement of Extracellular Regulated Kinase and p38 Kinase in Hippocampal Seizure Tolerance.J Neurosci Res. 81:581-588.

27.Zhang J,Wang JC,Han YH,Wang LF,Ji SP,Liu SX,Liu XP,Yao LB. (2005). High expression of bcl-x(L) in K562 cells and its role in the low sensitivity of K562 to realgar-induced apoptosis.Acta Haematol. 113:247-254.

28. Ji S, Liu X, Li S, Shen L, Li F, Wang J, Han J, Yao L.(2003). PH domain of G protein-coupled receptor kinase-2 binds to protein kinase C (PKC) and negatively regulates activity of PKC kinase.Front Biosci-landmrk. 8:a34-39.

29. Deng Y, Yao L, Chau L, Ng SS, Peng Y, Liu X, Au WS, Wang J, Li F,Ji S, Han H, Nie X, Li Q, Kung HF, Leung SY, Lin MC. (2003). N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation.Int J Cancer.106: 342-347.

30. Wang J, Lu H, Liu X, Deng Y, Sun T, Li F,Ji S, Nie X, Yao L (2002).Functional analysis of discoidin domain receptor 2 in synovial fibroblasts in rheumatoid arthritis.J Autoimmun. 19:161-168.

31. Li F, Yang Y, Liu X He P,JiS, Wang J, Han J, Chen N, Yao, L (2000). Human Glioma Cell BT325 Expresses a Proteinase That Converts Human Plasminogen to Kringle 1-5-Containing Fragments.Biochem. Biophys. Res. Commun. 278: 821-825.

32.JiSP,Yao LB,Bai YJ,Wang JC,Liu XP,Su CZ. Binding of Insulin Receptor Substrate 1 PH Domain to Protein Kinase C.Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai).1999;31(4):400-404.

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